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Highest Quality | For Research Use Only


Buy ACE-031 Japan Peptide

Ace-031 peptide, also known as ACVR2B or activin receptor type-2B, is a myostatin inhibitor that has been studied for its potential therapeutic applications in the treatment of muscle wasting diseases. Myostatin is a protein that regulates muscle cell growth and differentiation, and inhibiting its function can result in increased muscle mass and strength.

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Potential Benefits of Ace-031 Peptide

  • According to research, ACE-031 peptide exhibits potential in targeting myostatin/activin A signaling, which could be beneficial for treating diseases associated with muscle loss and metabolic dysfunction. This is primarily due to its ability to bind multiple members of the TGF-β family, thereby demonstrating its effectiveness as a receptor antagonist [1].
  • Clinical trials have shown that ACE-031 increases muscle mass and may be effective in treating conditions like cachexia and sarcopenia. The doses used in these studies ranged from 0.02 to 3 mg/kg, and subjects were randomized across six groups [2].
  • Studies suggest ACE-031 peptide has shown promise as a treatment for muscular dystrophy [3]. It was awarded orphan status and accelerated review by the FDA for this indication in 2010 [4].
  • Research indicates that ACE-031 is not just a selective inhibitor but also blocks BMP8, BMP9, and activins [5], expanding its potential application scope in muscle-related disorders.
  • ACE031, a modified version of ACVR2B, has been extensively studied for its potential therapeutic advantages in addressing sarcopenia, a condition characterized by loss of muscle mass and strength associated with aging.[6]. However, its development was halted due to safety concerns.
  • Postmenopausal women administered with ACE-031 showed an increase in lean body mass [7]. This research suggests potential use in countering muscle wasting conditions in postmenopausal women.
  • ACE-031 peptide significantly increased both type 1 and type 2 muscle fibers, according to a study [8]. This makes it a potential agent in enhancing overall muscle strength and function.
  • ACE-2494, an improved version of ACE-031, has been developed and has shown efficacy in stimulating muscle mass and bone growth [9]. This suggests the ongoing evolution and improvement of ACE-031 based treatments.


  1. https://academic.oup.com/bio medgerontology/article/78/ Supplement_1/32/7026116
  2. https://www.tandfonline.com/ doi/abs/ 10.1517/13543781 003724690
  3. https://onlinelibrary.wiley. com/doi/full/10.17987/ jcsm-cr.v2i1.37
  4. https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3819341/
  5. https://journals.lww.com/co-neurology/fulltext/2020/10000/ the_elusive_promise_of_ myostatin_inhibition_for.12. aspx
  6. https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7370765/
  7. https://www.sciencedirect.com/ science/article/abs/pii/S875632 8217303459
  8. https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7571243/
  9. https://onlinelibrary.wiley. com/doi/full/10.1002/agm2. 12168


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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Peptides website: https://japan.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.