Buy GHRP-2 Peptide
Buy GHRP-2, a growth hormone-releasing peptide, widely studied for its potential to stimulate natural growth hormone production. It has potential to support enhanced muscle growth, improved fat metabolism, and overall cellular repair.
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GHRP-2 CJC-1295 DAC Peptide Stack
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GHRP-2 Ipamorelin Peptide Stack
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Sermorelin & GHRP-2 Peptide Stack
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GHRP-2 10mg Pre Mixed
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GHRP-2 (Pralmorelin) Nasal Spray
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GHRP-2 (Pralmorelin)
£11.54 – £28.77 This product has multiple variants. The options may be chosen on the product page
What Is GHRP-2?
GHRP-2 Japan, also known as Pralmorelin or Growth Hormone Releasing Peptide 2, is a synthetic hexapeptide (6 amino acids) known for its ability to stimulate the secretion of growth hormone from the anterior pituitary gland. It acts as a ghrelin receptor agonist by binding to ghrelin receptors.
Also referred to as growth hormone secretagogue receptors (GHS-R), it triggers the natural production of GH in the body. This peptide is part of the secretagogue class and is considered highly effective in enhancing GH levels without the need for directly introducing synthetic hormones. It was studied as an experimental peptide for the treatment of GH deficiency and short stature.
By leveraging the body’s own mechanisms, Pralmorelin aids in processes such as tissue repair, muscle growth, fat metabolism, and improved overall energy levels. Furthermore, it is studied for its potential to address growth retardation, improve growth performance, and support anti-aging and recovery efforts, making it a promising tool in peptide research.
GHRP-2 Mechanism Of Action
GHRP-2 works by binding to the growth hormone secretagogue receptor (GHS-R), located in the pituitary gland and hypothalamus. This binding mimics the action of ghrelin, a natural hormone that stimulates appetite and triggers the release of GH.
When activated, the receptor starts intracellular signaling pathways involving enzymes like phospholipase C and protein kinase C. These pathways lead to a chain reaction that increases the release of growth hormone from the pituitary gland.
Additionally, GHRP-2 suppresses somatostatin, a hormone that inhibits GH release, further boosting its effects. By activating these pathways and reducing inhibitory signals, GHRP-2 significantly raises natural growth hormone levels, supporting tissue repair, metabolism, and cell growth. This targeted mechanism underscores GHRP-2’s potential for both research and therapeutic use.
Structure of GHRP-2
Sequence: H-D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2
Molecular Formula: C45H55N9O6
Molecular Weight: 818.0 g/mol
PubChem CID: 6918245
What Are The Research Benefits of GHRP-2
Enhanced Growth Hormone Secretion: It effectively increases the release of GH by stimulating the pituitary gland, which can support various growth and metabolic processes in the body [1].
Enhances muscle protein synthesis: by promoting the release of GH and insulin-like growth factor-1. This peptide has demonstrated its ability to support gains in lean body mass, even in difficult conditions, by decreasing protein breakdown and boosting protein accumulation, as evidenced in studies conducted on swine [2].
Improved Tissue Repair and Regeneration: By increasing GH levels, it may aid in the repair of damaged tissues, making it valuable for studies on healing and recovery [3].
Inflammation and Arthritis: It may provide insights into inflammatory conditions and arthritis. By reducing inflammation and aiding tissue repair, it could help develop treatments to ease joint pain and improve mobility [4].
Potential for Pain Relief: Japan Research suggests it may help modulate pain perception. By influencing growth hormone levels and specific pathways, it could aid studies on new pain management methods. In one study, it reduced pain in mice by activating GHS-R1α and δ- and κ-opioid receptors. It showed dose- and time-dependent effects, enhanced morphine’s pain relief, and may be a candidate for new pain-relief drugs [5].
Potential Metabolic Regulation: Elevated GH levels triggered by the peptide can influence metabolic pathways, potentially assisting in the regulation of fat metabolism and promoting lean muscle growth [6].
Support for Immune Function: GH is known to play a crucial role in supporting immunity by positively influencing immune responses. Its ability to enhance GH levels offers potential opportunities for further research into immune modulation and strengthening the body’s defence mechanisms [3].
Bone Density Support: Growth hormone plays a vital role in bone health, and it’s action may aid research into conditions affecting bone density or regeneration [7].
Reduced Somatostatin Activity: By suppressing somatostatin, a hormone that inhibits growth hormone secretion, Pralmorelin maximises the potential for consistent and sustained growth hormone release [8].
Studies on Appetite Stimulation: As an agonist of ghrelin, it may provoke appetite stimulation, which can be critical for research into eating disorders or appetite regulation [9].
Anti-Ageing Potential: The increase in gh production induced by Pralmorelin may contribute to studies focused on age-related decline, exploring its potential to mitigate signs of ageing and support cellular rejuvenation [10].
Insights into Cardiac Function: Some Japan studies have suggested that GH can have beneficial effects on heart function. It may therefore open up investigations into its potential effects on cardiovascular health [11].
Buy GHRP-2 pre-mixed peptide pen Japan for research online today! Pre-Mixed Cartridge Kits include a pre-filled cartridge, Bacteriostatic Water, a pen, carrying case, and needle tips. Single Mixed Cartridges come with just the cartridges and needle tips, available in sets of 1, 2, or 3, with a 10% discount on sets of 3.
Buy GHRP-2 CJC-1295 no DAC Peptide Stack
Buy GHRP-2 CJC-1295 No DAC peptide vial stack Japan is often used in research to explore potential benefits related to growth hormone release, increased muscle mass, improved metabolism, and enhanced recovery.
Buy GHRP-2 Nasal Spray
Buy GHRP-2 nasal spray Japan, available in 15 ml and 30 ml. This peptide may boost growth hormone levels to support muscle growth, fat loss, energy, and recovery.
Frequently Asked Questions (FAQs) about GHRP-2
What are the potential benefits of GHRP-2?
Japan Research suggests potential benefits include enhanced cellular regeneration, increased bone density, improved appetite regulation, and potential anti-ageing properties. It may also offer insights into better understanding cardiovascular and metabolic health.
Is GHRP-2 safe for use?
The safety depends on the context in which it is used. It is primarily intended for research and investigative purposes. Any use outside controlled studies should always follow professional and Japan regulatory guidelines.
What are common studies involving GHRP-2?
Japan Studies commonly investigate Pralmorelin for its role in growth hormone deficiency, eating disorders, age-related decline, and bone regeneration research. Its potential applications in cardiovascular function are also a growing field of interest.
Are there side effects associated with GHRP-2?
Some Japan studies suggest it may cause mild side effects such as increased appetite, temporary water retention, or slight changes in blood sugar levels. However, more research is necessary to fully understand its safety profile.
How is Pralmorelin administered in research settings?
It is typically administered via subcutaneous or intramuscular injection in controlled research environments. Dosage and frequency depend on the specific study protocol being followed.
Is GHRP-2 legal?
The legality varies depending on the country and its regulations. It is usually classified for research purposes only and not approved for human consumption outside of clinical studies. For instance, in the United States, the FDA has not approved it for therapeutic use, and it remains designated for investigative purposes in controlled research settings. Always consult local regulations before using or acquiring it.
Buy GHRP-2 Peptide Vial Japan from Direct Peptides. The lyophilized powder is available in 5mg and 10mg vials or as a kit with syringes and bacteriostatic water for reconstitution.
Summary of Research Applications
- Promotes growth hormone release
- Enhances skeletal muscle development
- Supports tissue repair
- Enhances pain relief
- Modulates inflammatory responses
- Potential arthritis treatment
- Helps regulate body weight
GHRP-2 Peptide Quality Assured
At Direct Peptides Japan, we provide Pralmorelin peptides with 99% purity, designed to meet high-quality standards for research use.
When you buy GHRP-2 peptides from us, you’re getting safe, reliable, and precise products.
References For Further Reading
[1] Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, et al (2016) Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation – PLoS One, 2016 Feb 19, Volume 11 (Issue 2), Page e0149461.
[2] L T Phung, A Sasaki, H G Lee, R A Vega, (2001) Effects of the administration of growth hormone-releasing peptide-2 (GHRP-2) orally by gavage and in feed on growth hormone release in swine – Domestic Animal Endocrinology, 2001 Jan, Volume 20 (Issue 1), Pages 9-19.
[3] Miriam Granado, Teresa Priego, Ana I Martín, M Angeles Villanúa, and Asunción López-Calderón (2004) Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats – American Journal of Physiology, Endocrinology and Metabolism, 2005 Mar, Volume 288 (Issue 3), Pages E486-92.
[4] Miriam Granado, Teresa Priego, Ana I Martín, Maria Angeles Villanúa, and Asunción López-Calderón (2005) Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle – American Journal of Physiology, Endocrinology and Metabolism, 2005 Dec, Volume 289 (Issue 6), Pages E1007-14.
[5] Ping Zeng, Shu Li, Yue-hui Zheng, Fu-Yan Liu, et al (2014) Ghrelin receptor agonist, GHRP-2, produces antinociceptive effects at the supraspinal level via the opioid receptor in mice – Peptides, 2014 May, Volume 55, Pages 103-9.
[6] Blandine Laferrère, Cynthia Abraham, Colleen D Russell, and Cyril Y Bowers (2018) Growth Hormone Releasing Peptide -2 (GHRP-2), like ghrelin, increases food intake in healthy men – Journal of Clinical Endocrinology & Metabolism, 2005 Feb, Volume 90 (Issue 2), Pages 611–614.
[7] M Kassem, L Mosekilde, and E F Eriksen (1994) Growth hormone stimulates proliferation of normal human bone marrow stromal osteoblast precursor cells in vitro – Growth Regulation, 1994 Sep, Volume 4 (Issue 3), Pages 131-5.
[8] Ali Iranmanesh, Cyril Y. Bowers, and Johannes D. Veldhuis (2004) Activation of Somatostatin-Receptor Subtype-2/-5 Suppresses the Mass, Frequency, and Irregularity of Growth Hormone (GH)-Releasing Peptide-2-Stimulated GH Secretion in Men Get access Arrow – The Journal of Clinical Endocrinology & Metabolism, Volume 89, Issue 9, 1 September 2004, Pages 4581–4587.
[9] J Tack, I Depoortere, R Bisschops, C Delporte, et al (2006) Influence of ghrelin on interdigestive gastrointestinal motility in humans – Gut, 2006 Mar, Volume 55 (Issue 3), Pages 327–333.
[10] Jane S Titterington, Sergiy Sukhanov, Yusuke Higashi, et al (2009) Growth Hormone-Releasing Peptide-2 Suppresses Vascular Oxidative Stress in ApoE−/− Mice But Does Not Reduce Atherosclerosis – Endocrinology, 2009 Oct 9, Volume 150 (Issue 12), Pages 5478–5487.
[11] G Muccioli, F Broglio, M R Valetto, C Ghè, F Catapano, et al (2000) Growth hormone-releasing peptides and the cardiovascular system – Annals d’Endocrinologie (Paris), 2000 Feb;61(1):27-31.
Why Choose Direct Peptides Japan?
Buy GHRP-2 Japan today from Direct Peptides, your trusted source for quality peptides. We offer a wide range of growth hormone releasing peptide options, including 5mg and 10mg vials, peptide stacks, nasal sprays in 15ml and 30ml bottles, and pre-mixed peptide pens and cartridges. Whatever your research needs, Japan Direct Peptides has the right formulation for your projects.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Japan Direct Peptides website: https://japan.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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